Cucurbit[7]uril as a Broad-Spectrum Antiviral Agent against Diverse RNA Viruses

• 作者: Jia Quan Xiangjun Zhang Yuanfu Ding Shengke Li Yang Qiu Ruibing Wang Xi Zhou
• 来源期刊: 中国病毒学
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: RESEARCH ARTICLES
• 页码范围: 1165-1176
• 页数: 12页
• 语种: 英文

摘要

The emergence and re-emergence of RNA virus outbreaks highlight the urgent need for the development of broad-spectrum antivirals.Polyamines are positively-charged small molecules required for the infectivity of a wide range of RNA viruses,therefore may become good antiviral targets.Cucurbit[7]uril (CB[7]),a synthetic macrocyclic molecule,which can bind with amine-based organic compounds with high affinity,has been shown to regulate bioactive molecules through competitive binding.In this study,we tested the antiviral activity of CB[7]against diverse RNA viruses,including a panel of enteroviruses (i.e.human enterovirus A71,coxsackievirus A16,coxsackievirus B3,and echovirus 11),some flaviviruses(i.e.dengue virus and Zika virus),and an alphavirus representative Semliki forest virus.CB[7]can inhibit virus replications in a variety of cell lines,and its mechanism of action is through the competitive binding with polyamines.Our findings not only for the first time provide evidence that CB[7]can be a promising broad-spectrum antiviral agent,but more impor-tantly,offer a novel therapeutic strategy to fight against RNA viruses by supramolecular sequestration of polyamines.