Modified Therapeutic Antibodies:Improving Efficacy

• 作者: Ji-Min Dai Xue-Qin Zhang Jing-Yao Dai Xiang-Min Yang Zhi-Nan Chen
• 来源期刊: 工程（英文）
• 年，卷（期）: 2021,（11）
• 所属期刊栏目: Immunology-Review
• 页码范围: 1529-1540
• 页数: 12页
• 语种: 英文

摘要

The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic anti-bodies for the treatment of cancers,inflammatory disorders,and refractory infections.As drawbacks emerge in clinical trials and practice,such as impeded binding,reduced effector functions,and frequent adverse reactions,modifications of therapeutic antibodies are unprecedently burgeoning in research and development(R&D).These modifications include:① modified glycosylation;② fragment of crystallizable domain(Fc)amino acid alterations;③ cross-isotype or cross-subclass exchanges;④ antibody-drug con-jugates(ADCs);⑤ single chain of variable region fragment(scFv)for chimeric antigen receptor T(CAR-T)cells;and ⑥ bispecific antibodies(bsAbs)in order to promote binding affinity,half-life in circulation,effectiveness toward target cells and,ultimately,to achieve overall improved efficacy.While many achievements have been made around the world in the past decades,China has been playing an active role in this realm,with its great demand for biotherapeutics with R&D potential.This review recapitulates the international progress that has been achieved with modified therapeutic antibodies,and then focuses on that of China in an independent section.