Bio-Nanocarriers for Lung Cancer Management:Befriending the Barriers

• 作者: Shruti Rawal Mayur Patel
• 来源期刊: 纳微快报（英文版）
• 年，卷（期）: 2021,（9）
• 页码范围: 368-421
• 页数: 54页
• 语种: 英文

摘要

Lung cancer is a complex tho-racic malignancy developing consequential to aberrations in a myriad of molecular and biomolecular signaling pathways.It is one of the most lethal forms of cancers accounting to almost 1.8 million new annual incidences,bear-ing overall mortality to incidence ratio of 0.87.The dismal prognostic scenario at advanced stages of the disease and metastatic/resistant tumor cell populations stresses the requisite of advanced translational interdisciplinary interventions such as bionanotechnology.This review article deliberates insights and apprehen-sions on the recent prologue of nanobioengi-neering and bionanotechnology as an approach for the clinical management of lung cancer.The role of nanobioengineered (bio-nano) tools like bio-nanocarriers and nanobiodevices in secondary prophylaxis,diagnosis,therapeutics,and theranostics for lung cancer management has been discussed.Bioengineered,bioinspired,and biomimetic bio-nanotools of consider-ate translational value have been reviewed.Perspectives on existent oncostrategies,their critical comparison with bio-nanocarriers,and issues hampering their clinical bench side to bed transformation have also been summarized.