Synthesis of 3-Methylthioindoles via Intramolecular Cyclization of 2-Alkynylanilines Mediated by DMSO/DMSO-d6 and SOCl2

• 作者: Xuemin Li Beibei Zhang Jingran Zhang Xi Wang Dongke Zhang Yunfei Du Kang Zhao
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Concise Reports
• 页码范围: 1211-1224
• 页数: 14页
• 语种: 英文
• DOI: 10.1002/cjoc.202000701

摘要

Main observation and conclusion The intramolecular cyclization of 2-alkynylanilines mediated by DMSO/SOCl2 was found to afford biologically interesting 3-methylthioindoles,which are rarely obtained by the exiting methods.DMSO could also be replaced with its deuterated counterpart,enabling the method applicable to the construction of indole skeleton bearing a SCD3 moiety at its 3-position.