Prevascularized Micro?/Nano?Sized Spheroid/Bead Aggregates for Vascular Tissue Engineering

• 作者: Maedeh Rahimnejad Narges Nasrollahi Boroujeni Sepideh Jahangiri Navid Rabiee Mohammad Rabiee Pooyan Makvandi Omid Akhavan Rajender S. Varma
• 来源期刊: 纳微快报（英文版）
• 年，卷（期）: 2021,（11）
• 页码范围: 351-374
• 页数: 24页
• 语种: 英文

摘要

Efficient strategies to promote microvascularization in vascular tissue engineering, a central priority in regenerative medicine, are still scarce; nano- and micro-sized aggregates and spheres or beads harboring primitive microvascular beds are promising methods in vascular tissue engineering. Capillaries are the smallest type and in numerous blood vessels, which are distributed densely in cardiovascular system. To mimic this microvascular network, specific cell components and proangiogenic factors are required. Herein, advanced biofabrication methods in microvascular engineering, including extrusion-based and droplet-based bioprinting, Kenzan, and biogripper approaches, are deliberated with emphasis on the newest works in prevascular nano- and micro-sized aggregates and microspheres/microbeads.