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This highlight presents a recent technique of "Light Vaccine" for COVID-19 pandemic control. Though this technique has the germicidal advantage to SARS-CoV-2, its shortcomings will limit the wide and in-depth application. We make a perspective of real nano light vaccine, which will play an important role in the prevention and control of COVID-19. Briefly, This flow chart described the MWCNT was fabricated with strong acid and base conditional mixture in order to achieve the p-WCNT (chemical process); then modified with RNA layse and receptor binding domain (RBD) by covalent conjugation and physical absorption to get f-WCNT (functionalization);thereafter, f-WCNT was used in the multi-cell culture system interacting with SARS-CoV-2 to identify the special affinity of f-WCNT to ACE2 labeled alveolar type Ⅱ cells and the inhibition capacity to SARS-CoV-2. This design, is different from the so called "light vaccine", has the real function to against SARS-CoV-2 by local cellular temperature-rising through photothermal conversion under the near infrared (NIR) light irradiation, according to the physical and chemical nature of carbon nanotubes, and initiates the immune response consequently.
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篇名 Real Nano "Light Vaccine" Will Benefit to COVID?19 Pandemic Control
来源期刊 纳微快报(英文版) 学科
关键词
年,卷(期) 2021,(11) 所属期刊栏目
研究方向 页码范围 421-422
页数 2页 分类号
字数 语种 英文
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纳微快报(英文)
月刊
2311-6706
31-2103/TB
上海市东川路800号
eng
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