Functional Surfactants for Molecular Fishing,Capsule Creation,and Single-Cell Gene Expression

• 作者: Mohammad Suman Chowdhury Xingcai Zhang Leila Amini Pradip Dey Abhishek Kumar Singh Abbas Faghani Michael Schmueck-Henneresse Rainer Haag
• 来源期刊: 纳微快报（英文版）
• 年，卷（期）: 2021,（9）
• 页码范围: 507-515
• 页数: 9页
• 语种: 英文

摘要

Creating a single surfactant that is open to manipulation,while maintaining its surface activity,robustness,and compatibility,to expand the landscape of surfactant-dependent assays is extremely challenging.We report an oxidation-responsive precursor with thioethers and multiple 1,2-diols for creating a variety of functional surfactants from one parent surfactant.Using these multifunctional surfactants,we stabilize microfluidics-generated aque-ous droplets.The droplets encapsulate different components and immerse in a bioinert oil with distinct interfaces where an azide-bearing surfactant allow fishing of biomolecules from the droplets,aldehyde-bearing surfactant allow fabrication of microcapsules,and hydroxyl-bearing surfactants,with/without oxidized thioethers,allow monitoring of single-cell gene expression.Creating multifunctional surfactants poses opportunities for broad applications,including adsorption,bioanalytics,catalysis,formulations,coatings,and programmable subset of emulsions.