Application of a real-ambient fine particulate matter exposure system on different animal models

• 作者: Yuanyuan Song Lifang Zhao Zenghua Qi Yanhao Zhang Guodong Cao Ruijin Li Lin Zhu Zhu Yang Chuan Dong Zongwei Cai
• 来源期刊: 环境科学学报（英文版）
• 年，卷（期）: 2021,（7）
• 页码范围: 64-70
• 页数: 7页
• 语种: 英文

摘要

Simulation of fine particulate matter(PM2.5)exposure is essential for evaluating adverse health effects.In this work,an ambient exposure system that mimicked real atmospheric conditions was installed in Taiyuan,China to study impacts of chronic PM2.5 exposure on adult and aged mice as well as Sirtuin3 knockout(Sirt3 KO)mice and wild-type(WT)mice.The real-ambient exposure system eliminated the possible artificial effects caused from exposure experiments and maintained the physiochemical characteristics of PM2.5.The case studies indicated that aged mice exhibited apparent heart dysfunction involving in-creased heart rate and decreased blood pressure after 17-week of real-ambient PM2.5 ex-posure.Meanwhile,15-week of real-ambient PM2.5 exposure decreased the heart rate and amounts of associated catecholamines to induce heart failure in Sirt3 KO mice.Additionally,the increased pro-inflammatory cytokines and decreased platelet related indices suggested that inflammation occurred.The changes of biomarkers detected by targeted metabolomics confirmed metabolic disorder in WT and Sirt3 KO mice after exposed to real-ambient PM2.5.These results indicated that the real-ambient PM2.5 exposure system could evaluate the risks of certain diseases associated with air pollution and have great potential for support-ing the investigations of PM2.5 effects on other types of rodent models.