Effect of Th1/Th2 balance on serum prostaglandin, COX-2, AVP and OT in primary dysmenorrhea rats with cold coagulation and blood stasis syndrome

• 作者: Feng-Ting Zhai Dong-Mei Wang Qing Ma Wei-Ping Cao Dan-Dan Wang Guang-Wen Li
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（15）
• 所属期刊栏目: Original article
• 页码范围: 1-5
• 页数: 5页
• 语种: 英文

摘要

Objective: Explore the role of Th1/Th2 balance in the pathogenesis of primary dysmenorrhea through study the effect of Th1/Th2 balance drift on serum prostaglandin F2α, prostaglandin, 6-keto-prostaglandin F1α, TXB2, COX-2, AVP and OT in Primary Dysmenorrhea Rats with cold coagulation and blood stasis syndrome. Method: The rat model of primary dysmenorrhea with cold coagulation and blood stasis syndrome was established. On the basis of this model, Th1 shift model and Th2 shift model were established. The rats were divided into blank group, model group, Th1 shifting group and Th2 shifting group. The writhing reaction of rats in each group was compared, and the contents of PGF2α, PGE2, 6-keto-PGF1α, TXB2, COX-2, AVP and OT in serum were detected. Results: Writhing latency: There was no significant difference between Th1 and Th2 shifting groups (P>0.05), Th2 shifting group was shorter than Th1 shifting group (P<0.05). Writhing times in 30 minutes: Compared with the model group, the writhing times of Th1 shifting group decreased significantly (P<0.01), while Th2 shifting group increased significantly (P<0.01). Compared with the blank group, the contents of PGF2α, TXB2, COX-2, AVP and OT were increased (P<0.05, P<0.01), and the contents of 6-keto-PGF1α and PGE2 were decreased (P<0.01). Compared with the model group, the contents of PGF2α, TXB2, COX-2 and AVP in Th1 shifting group were decreased (P<0.05, P<0.01), and the contents of 6-keto-PGF1α and PGE2 were increased (P<0.01), while the contents of PGF2α, TXB2, COX-2, AVP and OT in Th2 shifting group were increased (P<0.01), and the contents of 6-keto-PGF1α and PGE2 were decreased (P<0.01). Conclusion: The intervention of Th1/Th2 cell balance on the expression of PGF2α, PGE2, 6-keto-PGF1α, TXB2, COX-2, AVP and OT may be one of the pathogenesis of PD with cold coagulation and blood stasis syndrome.