The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants

• 作者: Ben Hu Ran Liu Xiaolu Tang Yuchen Pan Ming Wang Yongqing Tong Guangming Ye Gaigai Shen Ruochen Ying Aisi Fu Di Li Wanxu Zhao Jing Peng Jie Guo Dong Men Xinmin Yao Yirong Wang Hong Zhang Zhihui Feng Junping Yu Liangjun Chen Zixin Deng Xuemei Lu Ya-Ping Zhang Yirong Li Bende Liu Lilei Yu Yan Li Jian Lu Tiangang Liu
• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: BRIEF COMMUNICATIONS
• 页码范围: 136-138
• 页数: 3页
• 语种: 英文

摘要

Coronavirus disease 2019(COVID-19),the disease caused by infection with se-vere acute respiratory syndrome coron-avirus 2(SARS-CoV-2),has developed into a global pandemic that continues to pose an enormous threat to public health and the global economy.Since the first SARS-CoV-2 genome was released[1],thousands of genetic variants have been identified in SARS-CoV-2 strains isolated from worldwide patients.Some variants in the spike(S)protein have been re-ported to be associated with functional changes in viral transmissibility or viral loads,such as the D614G variant[2,3],the N501Y change,the P681H substitu-tion and deletion of AH69-AV70[4].However,there is currently little direct evidence linking the genomic variants and clinical severity of COVID-19.