Adult Mammalian Neurogenesis:Hopes and Challenges in the Repair of Spinal Cord Injury

• 作者: Zhaoyang Yang Wen Zhao Yudan Gao Hongmei Duan Peng Hao Fei Hao Xiaoguang Li
• 来源期刊: 工程（英文）
• 年，卷（期）: 2021,（12）
• 所属期刊栏目: Biomedical Engineering
• 页码范围: 1713-1714
• 页数: 2页
• 语种: 英文

摘要

Adult endogenous neurogenesis was first defined as the genera-tion of neurons and glia cells in the central nervous system(CNS);it was subsequently referred to as the activation of endogenous neural stem cells,and ultimately limited to the generation of new neurons[1].The research team led by Xiaoguang Li enriched this concept in 2015:Endogenous neural stem cells in the adult CNS can be activated,recruited,and migrated to the injured area,where these stem cells further differentiate into mature neurons.The new neurons may form a functional neural circuit with host neurons,resulting in function recovery[2].The main body of endogenous neurogenesis is neural stem cells,they can be self-renewable and multipotent,means that they can replicate and can produce different mature cell types.Neural stem cells in the central canal and/or its subregion of the spinal cord are activated.Most of them proliferate and differentiate into astrocytes(which are involved in scar formation)and a small number of oligodendro-cytes,with almost no new neurons[3].