Association between red blood cell distribution width and the occurrence of cervical carcinoma

• 作者: Ya-Ya Song Xin-Yi Zhu Yi-Ming Zhao
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（17）
• 所属期刊栏目: Original article
• 页码范围: 10-13
• 页数: 4页
• 语种: 英文

摘要

Objective: To explore correlation between red blood cell distribution width (RDW) and cervical carcinoma. Methods: 50 cervical carcinoma patients and 75 healthy controls from the First Affiliated Hospital of Soochow University from June 2020 to December 2020 were involved as the patients group and the control group respectively. Demographic data were collected from routine blood tests and biochemistry examination, the correlation of RDW with hemoglobin(Hb) and c-reactive protein(CRP) was evaluated by Spearman rank correlation, and receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic value of RDW for cervical carcinoma. Result: The levels of RDW,squamous cell carcinoma antigen (SCCA) and carcinoembryonic antigen (CEA) in patients with cervical carcinoma were higher than those in the controls. The levels of high-density lipoprotein(HDL),Albumin, Prealbumin, Hb, RBC and neuron-specific enolase (NSE) in patients were lower than those in the controls( all P<0.05) . There was no statistical significance on the difference in other markers between the two groups ( P>0.05) . The AUC of RDW in the diagnosis of cervical carcinoma was 0.834. Based on Spearman's rank correlation coefficient analysis, RDW was positively correlated with Hb (r=0.434,P<0.05) and CRP(r=0.366,P<0.05) RDW, and was negatively correlated with hematocrit(r=-0.363,P<0.05),in cervical carcinoma group, cervical carcinoma subgroup Ⅰ-Ⅱ and Ⅲ-Ⅳ were higher than the control group (P < 0.05).Conclusions: Elevated RDW is associated with the occurrence of cervical carcinoma,and it may have clinical value in the diagnosis of cervical carcinoma and the course of reaction.