Meta-analysis of efficacy of Taohong Siwu Decoction in the treatment of diabetic peripheral neuropathy

• 作者: Yi-Zhen Han Meng-Wei Fu Bo-Ning Cao Zhen Wang Yao-Xian Wang
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（17）
• 所属期刊栏目: Original article
• 页码范围: 47-54
• 页数: 8页
• 语种: 英文

摘要

Objective: To evaluate the clinical efficacy of combined/single use of Taohong Siwu decoction in the treatment for diabetic peripheral neuropathy(DPN) by meta-analysis. Methods: Database were searched electronically from the time databases established to November 2020 to collect randomized controlled trials of Taohong Siwu decoction combined with non-specific therapy for DPN in Chinese or English. The trial was assessed by 2 researchers independently, RevMan 5.3 software was used for meta-analysis. Results: A total of 13 studies included 970 patients. Meta-analysis showed that the combined/single use of Taohong Siwu decoction can further improve median sensory nerve velocity〔MD=4.86, 95％ CI (2.70, 7.03), P<0.00001〕, and the curative effect〔OR=4.35, 95％ CI (3.1, 6.06), P<0.00001〕, increase the velocity of the motor nerve〔MD=6.84,95％ CI (6.14, 7.55), P<0.00001〕,and the velocity of the sensory nerve〔MD=7.46, 95％ CI (5.84, 9.08), P<0.00001〕, decrease TCM syndrome score〔MD=-5.61, 95％ CI (-6.63, -4.60), P<0.00001〕, and fasting blood-glucose〔MD=-0.24, 95％ CI (-0.37, -0.11), P<0.00001〕. The GRADE showed B level of evidence. Conclusion: Combined/single use of Taohong Siwu decoction in the treatment for DPN is effective. The safety is not clear, and more high-quality clinical studies are expected to be included to provide evidence support.