Divergent Syntheses of Pyridoacridine Alkaloids via Palladium-Catalyzed Reductive Cyclization with Nitro-Biarenes

• 作者: Bo Liu Shuping Wang Changhao Bian Hongze Liao Hou-Wen Lin
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Concise Reports
• 页码范围: 1905-1910
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202100094

摘要

Main observation and conclusion A divergent and novel protocol for the preparation of both pyrido[2,3,4-k/]acridine and pyrido[4,3,2-k/]acridine alkaloids was devel-oped.This method featured the remote palladium-catalyzed reductive cyclization with Mo(CO)6 as reductant.A wide range of sub-strates including three types of nitro arenes were tolerated and afforded corresponding products in good to excellent yields.This method has been successfully applied to the total synthesis of norsegoline,styelsamine C and the skeleton of necatorone.