Molecular taxonomy of the primate amygdala via single-nucleus RNA sequencing analysis

• 作者: Lei Zhang Yanyong Cheng Shihao Wu Yufeng Lu Zhenyu Xue Xiao Chen Dai Chen Bo Zhang Zilong Qiu Hong Jiang
• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2021,（14）
• 所属期刊栏目: SHORT COMMUNICATIONS
• 页码范围: 1379-1383
• 页数: 5页
• 语种: 英文

摘要

The amygdala is an evolutionarily conserved brain region found in vertebrates.Accumulated pieces of evidence over the past few decades strongly suggest that the amygdala is involved in a wide range of behavioral responses,including social,aggressive,and parenting behaviors[1,2].In particular,amygdala dysfunction in humans is associated with psychiatric and emotional disorders[3,4].Although intensive studies have been carried out to analyze the role of the amygdala in rodents,the anatomical structure of the amygdala has changed enormously between rodents and pri-mates during evolution[1].Unlike in rodent brains,the basal and lateral amygdala(BLA)encompasses the major regions in the pri-mate brain,compared to the central amygdala(CeA)and medial amygdala(MeA)[1,5].The developmental and regional gene profil-ing of the amygdala in rhesus monkeys was previously performed[6].However,the gene expression information acquired through single-cell resolution is still not available.