Mechanistic Study of Oxidoreductase AprQ Involved in Biosynthesis of Aminoglycoside Antibiotic Apramycin

• 作者: Jinxiu Wang Suze Ma Wei Ding Tuo Chen Qi Zhang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Concise Reports
• 页码范围: 1923-1926
• 页数: 4页
• 语种: 英文
• DOI: 10.1002/cjoc.202100070

摘要

Main observation and conclusion The aminoglycoside antibiotic apramycin contains a unique bicyclic octose moiety,and biosynthesis of this moiety involves an oxi-doreductase AprQ.Unlike other known "Q" series proteins involved in aminoglycosides biosynthesis,AprQ does not work with an aminotransferase partner,and performs a four-electron oxidation that converts a CH20H moiety to a carboxylate group.In this study,we report mechanistic investigation of AprQ.