Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease

• 作者: Kai Zhang Shiou Zhu Jiamei Li Tingting Jiang Lu Feng Junping Pei Guan Wang Liang Ouyang Bo Liu
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2021,（10）
• 所属期刊栏目: Reviews
• 页码范围: 3015-3034
• 页数: 20页
• 语种: 英文

摘要

Parkinson's disease (PD),known as one of the most universal neurodegenerative diseases,is a serious threat to the health of the elderly.The current treatment has been demonstrated to relieve symp-toms,and the discovery of new small-molecule compounds has been regarded as a promising strategy.Of note,the homeostasis of the autolysosome pathway (ALP) is closely associated with PD,and impaired autophagy may cause the death of neurons and thereby accelerating the progress of PD.Thus,pharma-cological targeting autophagy with small-molecule compounds has been drawn a rising attention so far.In this review,we focus on summarizing several autophagy-associated targets,such as AMPK,mTORCl,ULK1,IMPase,LRRK2,beclin-l,TFEB,GCase,ERRα,C-Abelson,and as well as their relevant small-molecule compounds in PD models,which will shed light on a clue on exploiting more potential targeted small-molecule drugs tracking PD treatment in the near future.