Recent developments in the medicinal chemistry of single boron atom-containing compounds

• 作者: Shu Song Ping Gao Lin Sun Dongwei Kang Jacob Kongsted Vasanthanathan Poongavanam Peng Zhan Xinyong Liu
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2021,（10）
• 所属期刊栏目: Reviews
• 页码范围: 3035-3059
• 页数: 25页
• 语种: 英文

摘要

Various boron-containing drugs have been approved for clinical use over the past two de-cades,and more are currently in clinical trials.The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets;for example,boron substitution can be used to modulate biological activity,pharmacokinetic properties,and drug resistance.In this perspective,we aim to comprehensively review the current status of boron compounds in drug discovery,focusing espe-cially on progress from 2015 to December 2020.We classify these compounds into groups showing anti-cancer,antibacterial,antiviral,antiparasitic and other activities,and discuss the biological targets associated with each activity,as well as potential future developments.