Large π-extended donor-acceptor polymers for highly efficient in vivo near-infrared photoacoustic imaging and photothermal tumor therapy

• 作者: Jiangao Li Hanlin Ou Jing Li Xiaodi Yang Congwu Ge Dan Ding Xike Gao
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2021,（12）
• 所属期刊栏目: ARTICLES
• 页码范围: 2180-2192
• 页数: 13页
• 语种: 英文

摘要

Semiconducting polymers (SPs) with intensive near-infrared (NIR) absorption and high photothermal conversion efficiencies have been employed as a new generation of photothermal agents (PTAs) for "all-in-one" theranostic nanoplatforms with integrated photoacoustic imaging (PAI) and photothermal therapy (PTT) functions.However,the lack of facile molecular design principles impedes the development of highly efficient NIR PTAs.Herein,a facile molecular design strategy based on large π-extended donor-acceptor (L-n-D-A) structure is reported for achieving SPs (SP1-SP3) with highly efficient in vitro and in vivo PAI and PTT capabilities.Through adjusting the conjugation 1ength and planarity of the donor units,both SP3 and corresponding nanoparticle (SPN) SPN3 exhibit stronger D-A strength,intensive NIR absorption,enhanced absorption coefficient,and higher photothermal conversion efficiency (up to 61.8％).The excellent photothermal conversion efficiencies make SPN1-SPN3 produce efficient inhibition of tumor growth with excellent biocompatibility and prominent PAI performance with a high contrast manner in living mice at a low systemic injection mass.Our research highlights that the new L-n-D-A molecular design is an effective strategy to obtain highly efficient polymeric NIR PTAs for high desirable cancer phototheranostic nanoplatforms.