Multifunctional Polymer-Protein Conjugates Generated by Multicomponent Reactions

• 作者: Tengfei Mao Chongyu Zhu Lei Tao
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Recent Advances
• 页码范围: 2287-2295
• 页数: 9页
• 语种: 英文
• DOI: 10.1002/cjoc.202100153

摘要

Recently,multifunctional polymers for protein conjugation have been facilely synthesized through the multicomponent reactions(MCRs).In this mini-review,current progress in the generation of multifunctional polymers with protein-reactive groups via MCRs is summarized.These multifunc-tional polymers react with model therapeutic proteins,forming multifunctional polymer-protein conjugates,which are prototypes of sophisticated theranostic agents and antibacterial vaccine candidates.In comparison with the traditional multi-step synthesis,the preparation of multifunctional polymers for protein conjugation through MCRs is straightforward and convenient.Due to these properties,MCRs have the potential to become a new general strategy to achieve polymer-protein conjugates for biological and medical applications.