Shi Epoxidation:A Great Shortcut to Complex Compounds

• 作者: Xiangqing Feng Haifeng Du
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Cornerstones in Chemistry
• 页码范围: 2016-2026
• 页数: 11页
• 语种: 英文
• DOI: 10.1002/cjoc.202000744

摘要

Shi epoxidation provides an extremely powerful tool to access optically active epoxides,which undoubtedly belongs to one of the earliest and most successful organocatalytic systems.Several generations of chiral ketones have been developed to realize the asymmetric epoxidation of each type of unfunctionalized alkenes,including trans-,trisubstituted olefins,cis-olefins,terminal olefins,and tetrasubstituted olefins.Due to its reliability and high regio-and enantioselectivity,Shi epoxidation has been widely applied in the synthesis of complex natural products and biologically active molecules.