Recent Advances in Nanopore Sensing

• 作者: Mengjie Cui Yaxian Ge Xiao Zhuge Xin Zhou Dongmei Xi Shusheng Zhang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Recent Advances
• 页码范围: 2035-2043
• 页数: 9页
• 语种: 英文
• DOI: 10.1002/cjoc.202000721

摘要

Nanopore sensing is developing into a powerful label-free approach to investigate the features of biomolecules at the single-molecule level.When a charged molecule is captured within a nanopore,it modulates the ionic current,which can be recorded in real time to reveal the properties of the target molecule.To date,nanopores have been used to sense a variety of analytes,including DNA,RNA,proteins,enzymes,small molecules,cancer cells,and metal ions,and can also provide information on biomolecular structures.In this review,we highlight the progress made in nanopore sensing over the past five years (2016-2020),and provide an outlook on future developments and directions in the field.