Sulfur dioxide(SO2)was previously considered only as air pol-lutant.In 2008,our group first detected the endogenous SO2 gener-ating enzymes as well as its generating pathway in cardiovascular system[1].Our recent studies have shown that endogenous SO2 plays important cardiovascular physiologic regulatory roles and has pathophysiological significance.As such,we suggested that it serves as a new gasotransmitter[1-4].