Epoxymicranthols A—N,5,9-Epoxygrayanane Diterpenoids as Potent Analgesics from Rhododendron micranthum

• 作者: Pengfei Jin Xinghua Yuan Xiaomin Ma Guijuan Zheng Ru Wang Na Sun Guangmin Yao
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Comprehensive Reports
• 页码范围: 1997-2008
• 页数: 12页
• 语种: 英文
• DOI: 10.1002/cjoc.202100077

摘要

Main observation and conclusion Fifteen 5,9-epoxygrayanane diterpenoids (1-15) including fourteen new ones,epoxymicranthols A—N (1-14),were isolated from the leaves extract of Rhododendron micranthum.Their structures were elucidated via extensive spectroscopic methods and 13C NMR-DP4+ analysis,and the absolute configurations of 1,3-10,14,and 15 were confirmed by single-crystal X-ray diffraction analy-sis.Epoxymicranthols A—C (1-3) represent the first examples of 14α-hydroxygrayanane diterpenoids,and epoxymicranthols C—F(3-6) are the first examples of 10β-hydroxy-5,9-epoxygrayanane diterpenoids.