Clusterin: a multifaceted protein in the brain

• 作者: Hee-Jung Moon Liqin Zhao Sarah K.Herring
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Perspectives
• 页码范围: 1438-1439
• 页数: 2页
• 语种: 英文

摘要

Late-onset Alzheimer's disease (LOAD), themost common cause of dementia, currently affects 5.6 million Americans ages 65 and older. LOAD is a neurodegenerative disorder characterized by progressive loss in synaptic function, notable bioenergetic decline, increased neuronal death and brain atrophy, and significant cognitive impairment. Because the etiology of LOAD remains unknown, a treatment for LOAD has not yet been formulated, a fact that is clearly demonstrated by the more than 200 failed clinical trials.