Solubility measurement and thermodynamic modeling of carbamazepine (form Ⅲ) in five pure solvents at various temperatures

• 作者: Wenju Liu Zehua Bao Yanmin Shen Tiantian Yao Hongjuan Bai Xinyu Jin
• 来源期刊: 中国化学工程学报（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Chemical Engineering Thermodynamics
• 页码范围: 231-235
• 页数: 5页
• 语种: 英文

摘要

In this work, the solubilities of carbamazepine (CBZ) (form Ⅲ) in ethyl acetate, methyl acetate, ethylene glycol, chloroform and cyclohexylamine were determined by laser monitoring techniques at pressure above sea level, and the solubility data of CBZ (form Ⅲ) in different pure solvents were fitted by the Modified Apelblat model and kh model. The result shows that the solubility of CBZ (form Ⅲ) in five sol-vents increases as temperature rises, and the solubility in chloroform was the largest. The experimental solubility values of CBZ (form Ⅲ) in ethyl acetate, methyl acetate, chloroform and cyclohexylamine were in better agreement with the simulated fitting values of the kh model. For ethylene glycol, the r value was much larger than the other four solvents, and it can be seen from the kh model that ethylene glycol was closer to the ideal solution system than the other four solvents.