Targeting transglutaminase 2 as a potential disease modifying therapeutic strategy for synucleinopathies

• 作者: Hilary Grosso Jasutkar Jie Zhang M.Maral Mouradian
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Perspectives
• 页码范围: 1560-1561
• 页数: 2页
• 语种: 英文

摘要

Synucleinopathies are a group of progressive neurodegenerative disorders characterized by the accumulation of α-synuclein (α-Syn) aggregates in Lewy bodies (LBs) and Lewy neurites (LNs) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), and in glial cytoplasmic inclusions in multiple system atrophy (MSA).