Multi-axial three-dimensional printing of conical bioresorbable vascular scaffold

• 作者: Yu Du Jianlong Wang Sijing Wu Qing Liu Qinghong Zhao Yingxin Zhao Qian Ma Yujie Zhou
• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2021,（24）
• 所属期刊栏目: NEWS & VIEWS
• 页码范围: 2431-2433
• 页数: 3页
• 语种: 英文

摘要

Coronary artery disease (CAD) is the leading cause of death worldwide.Implantation of traditional cylindrical stents into the stenotic coronary arteries is widely used in patients with CAD.However,because most coronary arteries taper in diameter by at least 0.5 mm over a length of 20 mm [1],natural size mismatch is common between a cylindrical stent and a tapered coronary artery.This stent-vessel mismatch may directly cause either increased stress on both stent and vessel or incomplete stent appo-sition,followed by vessel injury,in-stent restenosis,or stent thrombosis [2,3].In particular,multiple-stent overlapping is needed in long tapered vessels,which results in shortened fatigue life or fracture of the metallic stent [4].Therefore,a patient-specific conical stent is theoretically desirable for a tapered vessel.This hypothesis is supported by our previous study using computa-tional fluid dynamics analysis,which demonstrated the intravascu-lar hemodynamic superiority of an implanted conical stent over a cylindrical one in a tapered vessel [5].BioMime (Meril Life Sciences,Gujarat,India) is one such currently available long tapered coronary stent,with proximal-to-distal diameters of 3.5-3.0,3.0-2.5,and 2.75-2.25 mm and lengths of 30,40,50,and 60 mm [6].The initial results of deploying the BioMime stent in long coronary lesions are promising,with a device success rate of approximately 97％ [7].However,concerns remain regarding the long-term safety and efficacy of the permanent metallic stent,as long as 45 mm on average,because of extensive inflammation and impaired vasomotor function in the stented vessel segment[8].In addition,the long full-metal-jacket artery may preclude coronary artery bypass in the future.