How would preclinical Alzheimer's disease (AD pathology) occur? An insight from a genomic instability mouse model

• 作者: Chinthalapally V.Rao Hiroshi Y.Yamada
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（10）
• 所属期刊栏目: Perspectives
• 页码范围: 2012-2014
• 页数: 3页
• 语种: 英文

摘要

More than 95％ of Alzheimer's disease (AD) is late-onset, in which patients show clinical cognition/behavior symptoms after age 65. Unlike early-onset AD that comes with mutations in genes directly involved in amyloid metabolism (APP, PSEN), genetic predispositions associated with late-onset AD are harder to pinpoint, and their mechanistic links to AD development need further investigation.