One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant:A strategy to modulate drug release for osteoporotic fracture healing

• 作者: Peng Wan Weidan Wang Lizhen Zheng Ling Qin Ke Yang
• 来源期刊: 材料科学技术（英文版）
• 年，卷（期）: 2021,（19）
• 页码范围: 92-99
• 页数: 8页
• 语种: 英文

摘要

Osteoporotic fracture with increase of aging population became an urgent orthopedic problem.Bisphos-phonates were widely recommended as effective clinical treatment drugs.Combination of biodegradable Mg-based implants and merits of bisphosphonates was suggested for osteoporotic fracture healing.Considering the mild and sustained drug release,a novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study.In comparison to conventional soaking method,encapsu-lated zoledronate coating by one-step electrodeposition method could modulate drug release in first diffusion-controlled and later degradation-controlled manner.The in vitro cell response to zoledronate loaded coating showed enhanced proliferation and osteogenic differentiation of osteoblasts and no sig-nificant inhibition on osteoclasts,which could improve bone-forming and decrease bone resorption due to osteoporosis.