The fatigue damage behavior of the nanocrystalline Au films on polyimide substrates was investigated.It was found that the very high-cycle fatigue damage resistance of the Au film was significantly enhanced by at least a factor of ~2 in supported loading through adding an ultrathin Ti interlayer at the Au film/polyimide interface.Such a better fatigue damage resistance is mainly ascribed to the effective suppression of voiding at the Au film/polyimide interface through modulation of the Au/Ti interface,and thus the propensity of the cyclic strain localization and grain boundary cracking is reduced.The finding may provide a potential strategy for the design of flexible devices with ultra-long fatigue life.