Apolipoprotein E and Alzheimer's disease

• 作者: Benjamin R.Troutwine Laylan Hamid Colton R.Lysaker Taylor A.Strope Heather M.Wilkins
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Special Column: Drug target and drug development for Alzheimer's disease
• 页码范围: 496-510
• 页数: 15页
• 语种: 英文

摘要

Genetic variation in apolipoprotein E(APOE)influences Alzheimer's disease(AD)risk.APOE e4 alleles are the strongest genetic risk factor for late onset sporadic AD.The AD risk is dose dependent,as those carrying one APOE ε4 allele have a 2-3-fold increased risk,while those carrying two ε4 alleles have a 10-15-fold increased risk.Individuals carrying APOE ε2 alleles have lower AD risk and those carrying APOE ε3 alleles have neutral risk.APOE is a lipoprotein which functions in lipid transport,metabolism,and inflammatory modulation.Isoform specific effects of APOE within the brain include alterations to Aβ,tau,neuroinflammation,and metabolism.Here we review the association of APOE with AD,the APOE isoform specific effects within brain and periphery,and potential therapeutics.