Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine: A review

• 作者: Nur Ellene Mat Luwi Suhana Ahmad Ahmad Suhaimi Nurfatihah Azlyna Asyikin Nordin Maria Elena Sarmiento Armando Acosta Mohd Nor Norazmi Vuk Uskokovi? Rohimah Mohamud Ramlah Kadir
• 来源期刊: 亚太热带医药杂志（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Review Article
• 页码范围: 7-16
• 页数: 10页
• 语种: 英文
• DOI: 10.4103/1995-7645.332806

摘要

Liposomes are phospholipid bilayer vesicles, which are biocompatible, biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery applications. In this review, we discuss the prospect of using liposome technology in the development of a vaccine for tuberculosis. Tuberculosis remains an important health problem that requires the development of an effective vaccine, especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin (BCG) one developed 100 years ago. This review focuses on the different applications of liposomes toward achieving this goal. Numerous liposomal formulations showing prospect in the research stage and in clinical trials are discussed.