The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin B1 (ITGB1)

• 作者: Ma Hai-Yang Xu Yan Qiao Chun-You Peng Yi Ding Qi Wang Li-Zhong Yan Jun-Fei Hou Yuan Di Fei
• 来源期刊: 中华神经外科杂志（英文）
• 关键词: Biomarker Immunohistochemical staining Inflammation Integrins Intracerebral hemorrhage Western blotting
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Research
• 页码范围: 10-15
• 页数: 6页
• 语种: 中文
• DOI: 10.1186/s41016-021-00234-4

摘要

Background::Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance.Methods::The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively.Results::Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues.Conclusions::In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.