Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

• 作者: Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 65-80
• 页数: 16页
• 语种: 英文

摘要

INTRODUCTION Low back pain (LBP) is a debilitating condition that affects～84％of the population in their lifetime.1 LBP affects physical function, reduces quality of life, and causes psychological distress.2 Although LBP is a multifactorial disease, studies report that intervertebral disc (IVD) degeneration is the main contributing factor.