Effect of Shengsui Jiangu capsule on TNF-α, TGF-β1, and empty bone lacuna in rats with alcoholic osteoporosis

• 作者: Shu-Jun Ren Jun-Tong Liu Chang-Jiang Yu Lei Jiang Fu-Zhu Tan Yi-Wei Shen Xi-Lin Xu
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Original article
• 页码范围: 20-24
• 页数: 5页
• 语种: 英文

摘要

Objective: To investigate the effect of postgraduate Shengsui Jiangu Capsule on tumor necrosis factors TNF-α,transforming growth factor TGF-β1 and empty bone lacuna in rats with alcoholic osteoporosis. Method: 120 SD rats were randomly divided into 4 groups, 30 rats in each group: blank group, model group, western medicine control group and traditional Chinese medicine intervention group.Liquor gavage was used to model the disease, except for the blank group. The western medicine control group was gavaged with a suspension of calcium carbonate and afad3, while the Chinese medicine intervention group was gavaged with a suspension of Shengsui Jiangu capsules combined with 0.9% saline solution injection. The values of TNF-α and TGF-β1 in femora were measured after 8, 12, and 16 weeks of intervention.After dissecting out the femoral head using the HE( hematoxylin-eosin staining) staining method, the bone lacunae were observed under a light microscope, and the empty bone lacunae rate was calculated for intergroup comparison. Results: Compared with the blank group, the model group had a significantly higher percentage of TNF-α and empty bone lacunae, and a significantly lower percentage of TGF-β1 (P < 0.01).Compared with the model group, the rates of TNF-α and empty bone lacunae in the western medicine control group and the Chinese medicine intervention group were significantly decreased, and TGF-β1 was significantly increased (P < 0.01).The traditional Chinese medicine intervention group was more effective than the western medicine control group (P < 0.05). Conclusion: Shengsui Jiangu capsule attenuates the expression of TNF-α, enhances the expression of TGF-β1, decreases the rate of empty bone lacunae, and achieves a protective effect against alcoholic osteoporosis in rats with alcoholic osteoporosis.