Preparation and properties of T-ZnOw enhanced BCP scaffolds with double-layer structure by digital light processing

• 作者: Ming-Zhu PAN Shuai-Bin HUA Jia-Min WU Xi YUAN Ze-Lin DENG Jun XIAO Yu-Sheng SHI
• 来源期刊: 先进陶瓷（英文版）
• 年，卷（期）: 2022,（4）
• 所属期刊栏目: Research Article
• 页码范围: 570-581
• 页数: 12页
• 语种: 英文

摘要

Bone scaffolds require both good bioactivity and mechanical properties to keep shape and promote bone repair.In this work,T-ZnOw enhanced biphasic calcium phosphate(BCP)scaffolds with triply periodic minimal surface(TPMS)-based double-layer porous structure were fabricated by digital light processing(DLP)with high precision.Property of suspension was first discussed to obtain better printing quality.After sintering,T-ZnOw reacts with β-tricalcium phosphate(β-TCP)to form Ca19Zn2(PO4)14,and inhibits the phase transition to α-TCP.With the content of T-ZnOw increasing from 0 to 2 wt％,the flexural strength increases from 40.9 to 68.5 MPa because the four-needle whiskers can disperse stress,and have the effect of pulling out as well as fracture toughening.However,excessive whiskers will reduce the cure depth,and cause more printing defects,thus reducing the mechanical strength.Besides,T-ZnOw accelerates the deposition of apatite,and the sample with 2 wt％T-ZnOw shows the fastest mineralization rate.The good biocompatibility has been proved by cell proliferation test.Results confirmed that doping T-ZnOw can improve the mechanical strength of BCP scaffolds,and keep good biological property,which provides a new strategy for better bone repair.