Tabernaesine J,a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon

• 作者: Wen-Fang Yi Tiwalade A.Adelakun Xue Bai Yu Zhang Xiao-Jiang Hao
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（4）
• 所属期刊栏目: Concise Reports
• 页码范围: 475-479
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202100634

摘要

Tabernaesine J(1),an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system,as well as one new biogenetically related vincamine-type indole alkaloid(2),were isolated from leaves of Tabernaemontana pachysiphon.Their structures were established by a combination of HRESIMS,NMR,single crystal X-ray diffraction,and ECD calculation.The unprecedented pen-ta-lactone ring in tabernaesine J(1)was postulated to be derived from acetyl-CoA enolate anion.Alkaloid 2 combined with fluconazole has the potential to overcome fluconazole resistance in Candida albicans.