The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells

• 作者: Zhenqing Liu Hye-Lim Lee Jin Sook Suh Peng Deng Chang-Ryul Lee Olga Bezouglaia Mojan Mirnia Vivian Chen Michael Zhou Zhong-Kai Cui Reuben H.Kim Min Lee Tara Aghaloo Christine Hong Cun-Yu Wang
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 95-106
• 页数: 12页
• 语种: 英文

摘要

INTRODUCTION Osteoporosis is a systemic disorder characterized by skeletal microarchitectural deterioration and reduced bone mass leading to fracture risks. The disease is multifactorial and caused by an imbalance between bone formation and resorption mediated by osteoblasts and osteoclasts, respectively.