The value of preoperative PLR and NLR in the prognostic evaluation of lung cancer

• 作者: Zi-Yan Shangguan Qi Chen Min Jiang Kai-Wen Hu
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Original article
• 页码范围: 31-37
• 页数: 7页
• 语种: 英文

摘要

Objective: To explore the relationship between platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) and prognosis of lung cancer patients before cold ablation. Methods: Retrospectively analyze the case data of primary lung cancer patients who underwent cryoablation of lung argon helium knife in our hospital from January 2012 to March 2018. PLR and NLR were calculated based on the blood routine data of the patients within 1 week before the operation. value. The patients were followed up. The deadline for follow-up was June 2021. The survival curve (ROC curve) was drawn according to the patient's survival prognosis, and the Youden index was calculated to determine the optimal cutoff value of PLR and NLR, and grouped based on this analysis. The correlation between pre-PLR level and NLR level with clinicopathological characteristics and prognostic survival time of patients with primary lung cancer. Results: The best cut-off point was calculated according to the ROC curve and divided into high PLR group (PLR≥155.72, n=127) and low PLR group (＜155.72, n=87); high NLR group (≥2.91, n=120) and Low NLR group (<2.91, n=94); preoperative high PLR, high NLR group pT, pN, pM and TNM staging compared with low value group, the difference was statistically significant (P<0.05); Cox multivariate Analysis shows that high PLR, high NLR, high pT staging, high pM staging, and high TNM staging are independent risk factors affecting postoperative survival; the postoperative survival rate of the high-level PLRNLR group was significantly lower than that of the other groups, and the difference was statistically significant. significance. Conclusion: The significant increase of NLR and PLT before operation in patients with primary lung cancer is associated with poor prognosis; the combination of the two has potential clinical application value in assessing the survival of patients after surgery.