Exploring COVID-19 at the single-cell level: a narrative review

• 作者: Chen Yifan Pu Jun
• 来源期刊: 生物组学研究杂志（英文）
• 关键词: COVID-19 neutralizing antibody SARS-CoV-2 single-cell sequencing vaccine
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Review Article
• 页码范围: 7-13
• 页数: 7页
• 语种: 中文
• DOI: 10.1097/JBR.0000000000000109

摘要

The coronavirus disease 2019 (COVID-19) pandemic has been an unmitigated disaster for society and the economy worldwide. However, much remains unknown about the pathogenesis of, treatment methods for, and preventive measures against COVID-19. Single-cell sequencing is a novel sequencing technology whose use has recently become prevalent in various life-science fields. This high-resolution technology is being used to analyze the COVID-19 pandemic at a single-cell level. In this review, we summarize the application of single-cell sequencing technology to the field of COVID-19-related research, including the biology of severe acute respiratory syndrome coronavirus 2, clinical concerns associated with COVID-19, neutralizing antibody screening, and vaccine development. We also address challenges to, and improvements in, existing single-cell research related to COVID-19.