Nuclear cGAS:sequestration and beyond

• 作者: Juli Bai Feng Liu
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: REVIEW
• 页码范围: 90-101
• 页数: 12页
• 语种: 英文

摘要

The cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type Ⅰ interferon and inflammation responses via the STING-dependent signaling pathway.In the past several years,a growing body of evidence has revealed that cGAS is also local-ized in the nucleus where it is associated with distinct nuclear substructures such as nucleosomes,DNA replication forks,the double-stranded breaks,and cen-tromeres,suggesting that cGAS may have other func-tions in addition to its role in DNA sensing.However,while the innate immune function of cGAS is well established,the non-canonical nuclear function of cGAS remains poorly understood.Here,we review our current understanding of the complex nature of nuclear cGAS and point to open questions on the novel roles and the mechanisms of action of this protein as a key regulator of cell nuclear function,beyond its well-established role in dsDNA sensing and innate immune response.