The current state of chemotherapy for the treatment of gastrointestinal stromal tumors with different genotypes: a narrative review

• 作者: Xu Yingying Hu Wenqing Xiao Keyuan Wang Feng Guan Wenxian Zong Liang
• 来源期刊: 生物组学研究杂志（英文）
• 关键词: chemotherapy gastrointestinal stromal tumor genotype treatment tyrosine kinase inhibitor
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Review Article
• 页码范围: 14-17
• 页数: 4页
• 语种: 中文
• DOI: 10.1097/JBR.0000000000000113

摘要

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the digestive system and are not sensitive to traditional chemotherapy. Therefore, historically, surgical resection was the only effective therapy. However, the emergence of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of GISTs, because they target c-Kit and PDGF receptor-α (PDGFRA), which are important in GIST development and progression. As research into c-Kit and PDGFRA continues, an increasing number of different TKIs are being used in the clinical setting. This review aims to discuss the current state of chemotherapy for the treatment of GISTs with different genotypes.