Fighting type 2 diabetes:Formulation strategies for peptide-based therapeutics

• 作者: Carlos Bendicho-Lavilla Iria Seoane-Via?o Francisco J.Otero-Espinar Asteria Luzardo-álvarez
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Reviews
• 页码范围: 621-636
• 页数: 16页
• 语种: 英文

摘要

Diabetes mellitus is a major health problem with increasing prevalence at a global level.The discovery of insulin in the early 1900s represented a major breakthrough in diabetes management,with further milestones being subsequently achieved with the identification of glucagon-like peptide-1(GLP-1)and the introduction of GLP-1 receptor agonists(GLP-1 RAs)in clinical practice.Moreover,the subcu-taneous delivery of biotherapeutics is a well-established route of administration generally preferred over the intravenous route due to better patient compliance and prolonged drug absorption.However,current subcu-taneous formulations of GLP-1 RAs present pharmacokinetic problems that lead to adverse reactions and treatment discontinuation.In this review,we discuss the current challenges of subcutaneous administration of peptide-based therapeutics and provide an overview of the formulations available for the different routes of administration with improved bioavailability and reduced frequency of administration.