Fluorescence Sensing of Glutathione Thiyl Radical by BODIPY-Modified β-Cyclodextrin

• 作者: Zhixue Liu Xianyin Dai Qiaoyan Xu Xiaohan Sun Yu Liu
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（4）
• 所属期刊栏目: Concise Reports
• 页码范围: 493-499
• 页数: 7页
• 语种: 英文
• DOI: 10.1002/cjoc.202100662

摘要

The fluorescence sensing of intracellular glutathione thiyl radical(GS·)is in great demand to seek the GS·-related pathophysiological events.Herein,boron-dipyrromethene(BODIPY)-modified β-cyclodextrin was developed for high-efficiency sensing of GS·,accom-panied by a fast response time(t1/2=218 s),with the detection limit of 468 nmol/L.Cell experiments indicated that the BODIPY-modified β-cyclodextrin could be applied to detect the GS·in live A549 cells.