Prospective application of poloxamer 188 in plastic surgery:A comprehensive review

• 作者: Yujia Shang Shiou Zhu Fangfei Niea Yonghuan Zhen Pengbing Ding Dong Li Hua Li Yang An
• 来源期刊: 中国整形与重建外科（英文）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Review
• 页码范围: 31-37
• 页数: 7页
• 语种: 中文

摘要

An increasing number of researchers have demonstrated that poloxamer 188 (P188) can be used as a pharma-ceutical excipient for clinical applications. Its membrane-sealing effects and inherent biological activities make it an extremely promising agent for plastic surgery. In this review, we summarize the positive roles of P188 in autologous fat grafting, wound healing, and cartilage transplantation. These roles include improving the survival rate of fat grafts and chondrocytes, stimulating the metabolic activity of adipocytes, promoting wound healing, and contributing to cartilage formation. Although further research is still needed, it is clear that P188 has great potential and application value in the field of plastic surgery.