Effects of T-2 Toxin Exposure on Bone Metabolism and Bone Development of Mice

• 作者: Cui Yi-long Cao Zheng Zhang Jian Song Miao Li Yan-fei
• 来源期刊: 东北农业大学学报（英文版）
• 学科: 农学
• 年，卷（期）: 2022,（1）
• 页码范围: 89-96
• 页数: 8页
• 分类号: S816.7
• 语种: 英文

摘要

T-2 toxin is the most widespread mycotoxin in crops, feed and food, which poses a serious threat to body health. Bone is the main target tissue for T-2 toxin accumulation. Ingestion of food contaminated by T-2 toxin is the main cause of Kashin-Beck disease. However, the specific mechanism of bone damage caused by T-2 toxin is still unclear. In this study, a total of 40 male C57BL/6N mice were divided into four groups and orally treated with 0, 0.5, 1.0 and 2.0 mg ? kg-1 body weight T-2 toxin for 28 days. The results showed that exposure to T-2 toxin led to weight loss, bone mineral density reduction and femoral structural damage of mice. In addition, osteoblast-mediated bone formation was inhibited, and osteoclast-mediated bone resorption was enhanced. Meanwhile, the levels of bone metabolism-related hormones including parathyroid hormone, calcitonin and 1, 25-dihydroxyvitamin D3 were reduced. More importantly, it was found that the level of neuropeptide Y (a neurohormone) was decreased. These results provided a new perspetive for understanding the osteotoxicity of T-2 toxin.