Efficacy and safety of Shenshuaining granule combined with Western medicine treatment intreatment of diabetic kidney disease: A meta-analysis

• 作者: Shou-Yu Huang Ning Zhang Ting Fang Rong-Lu Yang
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Original article
• 页码范围: 43-48
• 页数: 6页
• 语种: 英文

摘要

Objective: To systematically review the efficacy and safety of Shenshuaining granule combined with Western medicine treatment for Diabetic kidney disease (DKD) by meta-analysis. Methods: Databases including CNKI, WanFang Data, VIP, CBM, TheCochrane, Embase and PubMed were electronically searched from inception to May 2020 to collect randomized controlled trials of Shenshuaining granule with western medicine treatment for Diabetic nephropathy. The trial was screenedbased on inclusion and exclusion criteria, and the methodological quality of the included relevant trial was assessed by Cochrane Handboo-k. Meta-analysis was then performed by Revman 5.3 software. Results: A total of 9 studies involving 892 patients were included. Both groupinclude 446 patients.The result of meta-analysis showed that Shenshuaining granule combined with Western medicine treatment significantly improved the total effective rate of diabetic nephropathy [RR=1.26,95%CI (1.17,1.37),P<0.00001], further reduced ser umurea nitrogen [MD=-1.65,95%CI(-2.53,-0.77),P=0.0002], 24h urine albumin excretion rat [SMD=-4.21,95%CI(-6.23,-2.19),P<0.0001], serum creatinine [MD=-21.50,95%CI(-28.48,-14.50),P<0.00001]. However, the difference of fasting blood glucose [MD=-0.46,95%CI(-1.18,0.27),P=0.22]was not statistically significant. Conclusions: Shenshuaining granule can improve the rate o-f renal pellet filtration in patients with diabetic nephropathy, reduce kidney injury and protect kidney function.Although there are sideeffects, it is relatively safe.