Cell-cycle length of medial ganglionic eminence progenitors contributes to interneuron fate

• 作者: Ni Zong Min Wang Yinghui Fu Dan Shen Yong-Chun Yu
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: LETTERS
• 页码范围: 141-147
• 页数: 7页
• 语种: 英文

摘要

Dear Editor, GABAergic intemeurons contribute to cortical function by regulating the balance of activity.Malfunction of inhibitory interneurons has been associated with neuropsychiatric disorders (Hashimoto et al.2003;Marín 2012).The most striking feature of GABAergic interneurons is their diversity of cell types.Although fate-mapping studies have demon-strated the presence of spatially and temporally distinct progenitor domains for interneuron subclasses within the embryonic ventral telencephalon (Butt et al.2005;Inan et al.2012),the mechanisms of interneuron subtype-determina-tion during development remain poorly understood.