Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

• 作者: Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Beno?t Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 137-149
• 页数: 13页
• 语种: 英文

摘要

INTRODUCTION The most common form of dwarfism, achondroplasia (ACH), is caused by a gain-of-function mutation in the FGFR3 gene encoding fibroblast growth factor receptor 3.1 FGFR3 gain-of-function mutations are also associated with hypochondroplasia, mild dwarfism, thanatophoric dysplasia (TD), and severe and lethal dwarfism.